In spite of and although:

IN SPITE OF:
"I'm no better in spite of the pills/in spite of taking the pills."
"laura wants to fly in spite of her fear/in spite of feeling afraid NOT in spite of she feels afraid


ALTHOUGH
"I'm no better, although I've taken the pills."
"laura wants to fly, although she feels afraid."


we can use in spite of the fact (that) in the same way as although. I'm no better in spite of the fact that I've taken the pills.